Yeah so I run Windows 7 x64 on a C2D laptop, 4 GB, SSD, I'm running 1.11.06b, TableNinja on Pokerstars. I've gone trough the "Performance tips" sticky. I've also done the vacuum thing.
The issue is, when I restart my computer, launch a session and start loading up tables (up to 35) everything works without a hitch. After some time (could be an hour our two), a massive lag starts. E.g., I click on "fold" and it takes PS a couple of seconds to process the action. Then I start timing out across 30+ tables and everything goes into meltdown.
Closing the table finder fixes this lag immediately, no lag and everything goes smoothly, HEM imports the hands. Upon relaunching the HUD/Table Finder everything goes back to laggy mode.