I had the same problem.
I did investigate different things myself I did reinstall TN2 no results and after that i found out that the problem is in the user.ini from pokerstars. I did also uninstalled pokerstars . Before that i did make a copy of my user.ini and notes. After the reinstalled i notest that the table was set in place and the hotkeys seems to work. After copied my user.ini back it did not work anymore So did al the settings in the client and copied my favorites back into the user.ini.
So Delete you user.ini from pokerstars ....\AppData\Local\Pokerstars.eu\user.ini and i guess you'll be fine. Don't forget to set a copy aside in case u need it.
Set you preference manually in the client again and restart pokerstars.