If you are treating poker as a business than you have to think as if you are running a small retail outlet. How to make the most profit in the hours your shop is open for the least amount of work. You have x amount of money to invest and so you think carefully about what you should sell before you spend a cent of your BR. The long term ROI for different poker variants varies a great deal - it depends on three things
[1] The difference in ability between the best & worst players in that game at that stake
[2] The software tools available for that particular variant
[3] The rake taken by the site owners & the invisible "rake" taken by thieves
I am going to use GAME SELECTION to illustrate my point:- STT S'n'Gs, DoN S'n'G are the perfect game for colluders. Even the best STT players can't beat colluders - so why would you open a shop at all in an area known to be full of armed robbers & shop lifters? 1,000s of players fell in love with playing DoNs with no thought to the consequences. PokerStars paid out $2M to players cheated by a ring of 50 colluders a few years ago & they have paid out a lot more than that in many smaller cases. PS got rid of DoNs because of this.
PokerStars pays $2 million to players affected by Chinese collusion ring
It is up to you to maximise your bb/100 rate & to have a deep BR. A deep BR means you can play the high variance games some of which have the biggest bb/100 in poker. It seems crazy to me to play NLHE when there are other games with a bigger difference in skill edge between top 20% & bottom 20% of players. Why not have some pain for three months learning a new game if it means you can triple your bb/100 in the long run?
Some sites have their own bots [it's in their ToS] because otherwise they couldn't fill their tables & attract depositors. Bots are probably not a big problem now, but it is wise to think ahead - avoid the simple games with 40bb-100bb stacks & try to learn something much less beatable by bots such as 250bb PLO. Playing against a bot is probably profitable but playing against a network of colluding bots will bust you. It is bot collusion, multi-tabling regs [& seating scripts] that is forcing all the sites to move to anon tables & invisible lobbies - they need to look after their net depositor recreational players.
The higher you play the smaller the skill edge gap, the larger the risk of ruin & the larger the potential profit. Therefore the higher you go the more likely it is you'll run into scams & cheating - it's an obvious move for the top players to form groups that share HHs for "study purposes"