When I disable notecaddy HM2 works like a charm
HM2 conf fileHoldemManager.7z
I have about 5 stats in my popups+lists(http://scr.hu/0p4g/6fs9q).
Of course I'm using NCE Ultimate. And it was working fine with 50% of notes enabled but then I enabled all of the notes from package.
Database size: 32GB
SSD: 128GB (25GB of free space)
I had made like 8 custom stats and noticed that they have total runtime higher than the rest (average: 600k, custom: 1.5k)