Check if there are handhistory files 'stuck' in the auto import folders, and manually move all files to the archive folder, C:/HMArchve.
Which Operating System, Firewall, and Anti-Virus are you using?
For W7 and Vista you must set \holdem manager\dbcontrolpanel.exe, holdemmanager.exe and hmhud.exe are started as administrator. Run the windows explorer and navigate to your Holdemmanager installation directory. Right click the executables and select properties... then select "Run as admin" from the compatibility tab.
Add exceptions to the windows firewall for holdemmanager.exe and hmhud.exe, even if the firewall is turned off. If you have a 3rd party firewall, do the equivalent or uninstall it temporarily.
Make sure your video card drivers and windows auto updates are fully updated. Run a manual Windows Update and install all updates, including all .net fra mework updates.
--
Update to:
http://www.holdemmanager.com/Downloa..._27Mar2012.exe
Note the HM1 update will perform a big database update when you run it.
So ignore any "not responding" error but wait for the program to unfreeze and the database update to finish.
Make sure you have enough free diskspace.
If you have a 40 GB database--> the database update would like 10 GB of free space (to use temporarily)
Run dbcontrolpanel.exe and create a new database, if you get an error upon startup.