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Run the windows explorer and navigate to your Holdemmanager2 installation directory. Right click the executables and select properties... then select "Run as admin" from the compatibility tab.
Add exceptions to the windows firewall for those files even if the firewall is turned off. If you have a 3rd party firewall, do the equivalent or uninstall it temporarily.
Run a manual Windows Update and install all updates, including all .net framework updates.
Turn off User Account Control:
How to Disable and Turn Off UAC in Windows 7 « My Digital Life
When there is a crash, please sent your full log.txt file, located in the following folder to
hm2support@holdemmanager.com:
Windows 7: C:\Users\{username}\AppData\Roaming\HoldemManager\
XP: c:\documents and settings\{username}\appdata\HoldemManager