In the meantime I did everything suggested except the logging but no improvement at all. Also the deinstallation of my NOD32 antivirus didn't help. The auto pop-up feature does still not work on PS live tables but it does in hand viewer. I'll enable the logging now and open a support ticket again. I think this is a HM2 problem on Win 10. On my older notebook running Win 7 it works fine.
By the way, this issue has been reported before about two weeks ago but unfortunately no solution described in the thread.
http://forums.holdemmanager.com/gene...dont-open.html