* Please try updating to the latest version 1.10.02
http://rvgsoftware.fileburst.com/HmBetaUpdate.exe
* Under Vista and Windows 7 make sure that holdemmanager.exe, hmhud.exe and dbcontrolpanel.exe are started as administrator. Run the windows explorer and navigate to your Holdemmanager installation directory. Right click the holdemmanager.exe, dbcontrolpanel.exe and the hmhud.exe executable and select "Run as admin" from the popup menu under compatibilty.
Make sure FT is setup correctly
FAQ - Hold'em Manager Poker Tracking Software :: Full Tilt Setup
* If that doesn't help, please check this and answer the questions at the bottom
FAQ - Hold'em Manager Poker Tracking Software :: My HUD Doesn't Work